diff --git a/backend/open_webui/config.py b/backend/open_webui/config.py
index 13dce96a02..ff1c01daa9 100644
--- a/backend/open_webui/config.py
+++ b/backend/open_webui/config.py
@@ -1366,10 +1366,11 @@ if THREAD_POOL_SIZE is not None and isinstance(THREAD_POOL_SIZE, str):
 def validate_cors_origin(origin):
     parsed_url = urlparse(origin)
 
-    # Check if the scheme is either http or https
-    if parsed_url.scheme not in ["http", "https"]:
+    # Check if the scheme is either http or https, or a custom scheme
+    schemes = ["http", "https" ] + CORS_ALLOW_CUSTOM_SCHEME
+    if parsed_url.scheme not in schemes:
         raise ValueError(
-            f"Invalid scheme in CORS_ALLOW_ORIGIN: '{origin}'. Only 'http' and 'https' are allowed."
+            f"Invalid scheme in CORS_ALLOW_ORIGIN: '{origin}'. Only 'http' and 'https' and CORS_ALLOW_CUSTOM_SCHEME are allowed."
         )
 
     # Ensure that the netloc (domain + port) is present, indicating it's a valid URL
@@ -1384,6 +1385,11 @@ def validate_cors_origin(origin):
 # in your .env file depending on your frontend port, 5173 in this case.
 CORS_ALLOW_ORIGIN = os.environ.get("CORS_ALLOW_ORIGIN", "*").split(";")
 
+# Allows custom URL schemes (e.g., app://) to be used as origins for CORS.
+# Useful for local development or desktop clients with schemes like app:// or other custom protocols.
+# Provide a semicolon-separated list of allowed schemes in the environment variable CORS_ALLOW_CUSTOM_SCHEMES.
+CORS_ALLOW_CUSTOM_SCHEME = os.environ.get("CORS_ALLOW_CUSTOM_SCHEME", "").split(";")
+
 if CORS_ALLOW_ORIGIN == ["*"]:
     log.warning(
         "\n\nWARNING: CORS_ALLOW_ORIGIN IS SET TO '*' - NOT RECOMMENDED FOR PRODUCTION DEPLOYMENTS.\n"